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Image Search Results
Journal: Cancers
Article Title: MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
doi: 10.3390/cancers15235557
Figure Lengend Snippet: Summary of deregulated miRNAs in ALD and cited in this review.
Article Snippet: MiR-10a , PI3K/AKT/mTOR , HCC patients,
Techniques: Expressing, Transformation Assay, Activation Assay, Migration
Journal: Cancers
Article Title: MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
doi: 10.3390/cancers15235557
Figure Lengend Snippet: ( A ) A transcriptomic dataset (GSE59492 from Gene Expression Omnibus Database) was used to analyze deregulated miRNAs between control and alcohol-related cirrhotic livers ( B ) A literature-based screening was used to classify them in oncomiRs or tumor suppressor miRNAs (miRsupressors). ( C ) Among deregulated miRNAs, some have unknown functions in HCC. ( D ) Overexpression of some of these microRNAs, such as miR-3622a, can be observed in HCC tumors (data retrieved from miRTV database in July 2023). ( E ) The same transcriptomic dataset (GSE59492) was used to compare deregulated miRNAs in alcohol-related cirrhosis with NASH related cirrhosis. Only two miRNAs (miR-4725 and miR-150) are commonly upregulated in both conditions, and one miRNA is commonly downregulated (miR-3162).
Article Snippet: MiR-10a , PI3K/AKT/mTOR , HCC patients,
Techniques: Gene Expression, Control, Over Expression
Journal: Cancers
Article Title: MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
doi: 10.3390/cancers15235557
Figure Lengend Snippet: Summary of deregulated miRNAs and their impacts on different pathways associated with HCC.
Article Snippet: MiR-10a , PI3K/AKT/mTOR , HCC patients,
Techniques: Inhibition, Cell Differentiation, Migration, Histone Deacetylase Assay, Blocking Assay
Journal: Cancers
Article Title: MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
doi: 10.3390/cancers15235557
Figure Lengend Snippet: ( A ) A transcriptomic dataset (GSE10694) was used to identify new miRNAs deregulated in hepatocellular carcinoma with alcohol abuse. The data are represented in a heatmap showing the log2 fold change of deregulated miRNAs. ( B ) Significantly deregulated microRNAs were subjected to literature-based screening to classify them in the most common HCC-related pathways. The data were retrieved in July 2023. miRNAs in red bubbles: upregulated; miRNA in blue bubbles: downregulated. Black arrows: activation of the pathway; Blue inhibitory arrows: pathway inhibition. Created with Biorender.com .
Article Snippet: MiR-10a , PI3K/AKT/mTOR , HCC patients,
Techniques: Activation Assay, Inhibition